Fecal samples were collected and profiled using 16S rRNA sequencing. One hundred eighty-four community-dwelling adults (28–97 years) completed validated self-report-based measures of loneliness, wisdom, compassion, social support, and social engagement. The present study aimed to investigate the association of loneliness and wisdom with the gut microbiome. We have consistently found a strong negative correlation between loneliness and wisdom. Wisdom is associated with better health and well-being. Loneliness is a serious public health problem associated with increased morbidity and mortality. Loneliness and wisdom have opposite effects on health and well-being. 9Department of Neurosciences, University of California, San Diego, La Jolla, CA, United States.8Department of Bioengineering, University of California, San Diego, La Jolla, CA, United States.7Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CA, United States.
1Department of Psychiatry, University of California, San Diego, La Jolla, CA, United States.Nguyen 1,2,3,4 *, Xinlian Zhang 5, Tsung-Chin Wu 2,5, Jinyuan Liu 2,5, Collin Le 2, Xin M.